MENU CLOSE
About Us

Who We Are

Our Social Responsibility

Events

Exhibitions

Activeties

Members

Hospitals

Individuals

Companies

Member Benefits

 
Bio-medical projectsi

State Key Laboratory of Biotherapy

Cooperation

Achievement Exhibition

Scimea Journals

Signal Transduction and Targeted Therapy

News

News Information

 
Home   >  News
30 Oct 2020
445
MedComm | Comparison of indocyanine green and methylene blue use for axillary reverse mapping during axillary lymph node dissection
SCIMEA

Approximately 30% of patients with breast cancer harbor regional lymph node metastases. Although complete level I and II axillary lymph node dissection (ALND) remains the standard of care in this setting, the associated morbidity is significant due to upper limb effects, including lymphedema, seroma, dysfunction, and sensory loss. Lymphedema of the upper extremity is particularly debilitating and ostensibly results from disrupted lymphatic drainage at the axilla. Axillary reverse mapping (ARM) has been used to trace lymphatics and lymph nodes from the upper extremity, so that drainage is preserved and resultant lymphedema is curtailed.


image.png


This study compared the feasibility of ARM using indocyanine green (ICG) or methylene blue (MB), and accessed the oncologic safety of the procedure. Overall, 158 patients qualified for ALND were enrolled. The characteristics of ARM‐identified nodes were recorded with ICG (n = 78) or MB (n = 80) visualization. Fine‐needle aspiration cytology (FNAC) of the nodes were performed and validated by histologic analysis. The nodal identification rate in the ICG group significantly surpassed that of the MB group (87.2% vs 52.5%, P < .05) with fewer complications. Note that 10.9% of the patients had metastatic involvement of the ARM‐identified nodes. Also 80% of the positive nodes were found in areas B and D, while the ARM‐identified nodes mainly located in area A. All the 51 nodes diagnosed as negative of malignancy by FNAC were free of metastasis. Nodal metastasis was significantly correlated with extensive nodel involvement, advanced disease, and the characteristics of identified nodes. In conclusion, ICG appears superior to MB for ARM nodes identification. FNAC, together with the features of primary tumors and ARM nodes, can delineate which nodes could be preserved during ALND.


1604053606815452.png


 Fig.1 The location of nodes identified by ARM during ALND and dye injection sites



Article Accesshttps://onlinelibrary.wiley.com/doi/full/10.1002/mco2.31

 

 

                                                                                                                                                      

Website for MedCommhttps://onlinelibrary.wiley.com/journal/26882663

Looking forward to your contributions.




West China Hospital Intensive Care Summer Camp Concluded | Bonus Scenes for You (Part II)
MedComm | A dual MET/AXL small‐molecule inhibitor exerts efficacy against gastric carcinoma through killing cancer cells as well as modulating tumor microenvironment
MedComm | Comparison of indocyanine green and methylene blue use for axillary reverse mapping during axillary lymph node dissection
Activity Review | Those Things about Tits
Taste Chinese Tea, Feel Chinese Culture | International Students Tea Party
Latest Events Journals News Members About Us Home
Contact Us

Address: No. 1103-1105, Building 6, S2, Global Center, High-tech Zone, Chengdu

Email: scimea@163.com 

Tel: (0086-)028-63859818   

Fax: (0086-)028-63859818   

Contact: (0086-)19113901604 (wechat:19113901604)


Follow Us
Copyright © 2009-2019 SCIMEA. All rights reserved 蜀ICP备19011649号-1