MENU CLOSE
About Us

Who We Are

Our Social Responsibility

Events

Exhibitions

Activeties

Members

Hospitals

Individuals

Companies

Member Benefits

 
Bio-medical projectsi

State Key Laboratory of Biotherapy

Cooperation

Achievement Exhibition

Scimea Journals

Signal Transduction and Targeted Therapy

News

News Information

 
Home   >  News
09 Jun 2020
386
MedComm | Intermedin promotes vessel fusion by inducing VE‐cadherin accumulation at potential fusion sites and to achieve a dynamic balance between VE‐cadherin‐complex dissociation/reconstitution
Scimea

A closed vascular system is always established by vessel fusion. However, it has been an unsolved mystery that how vessel fusion happened in this process. In this study, Lingmiao Kong et al reported that intermedin (IMD), a calcitonin family member, promotes vessel fusion by inducing endothelial cells (ECs) to enter a “ready‐to‐anchor” state.

 



1598427876(1).png


To create a closed vascular system, angiogenic sprouts must meet and connect in a process called vessel fusion, which is a prerequisite for establishment of proper blood flow in nascent vessels. However, the molecular machinery underlying this process remains largely unknown. Herein, we report that intermedin (IMD), a calcitonin family member, promotes vessel fusion by inducing endothelial cells (ECs) to enter a “ready‐to‐anchor” state. IMD promotes vascular endothelial cadherin (VEC) accumulation at the potential fusion site to facilitate anchoring of approaching vessels to each other. Simultaneously, IMD fine‐tunes VEC activity to achieve a dynamic balance between VEC complex dissociation and reconstitution in order to widen the anastomotic point. IMD induces persistent VEC phosphorylation. Internalized phospho‐VEC preferentially binds to Rab4 and Rab11, which facilitate VEC vesicle recycling back to the cell‐cell contact for reconstruction of the VEC complex. This novel mechanism may explain how neovessels contact and fuse to adjacent vessels to create a closed vascular system.

 

 


 图片(1).jpgFig. 1 IMD promotes vessel fusion in vitro and in vivo.

 

 

 

Article Access: https://onlinelibrary.wiley.com/doi/10.1002/mco2.9

 

 

                                                                                                               

Website for MedComm: https://onlinelibrary.wiley.com/journal/26882663

Looking forward to your contributions.


Activity Review | Those Things about Tits
News | Suining Central Hospital Science Popularization Activities
Review of Academic Reports at the State Key Laboratory of Biotherapy, Sichuan University
Interview | Daisaku Sato: Mutual Learning Essential to Drug Administrations for Constant Improvement
Oncology Multidisciplinary Treatment (MDT) Professional Committee Officially Founded under Sichuan International Medical Exchange & Promotion Association
Latest Events Journals News Members About Us Home
Contact Us

Address: No. 1103-1105, Building 6, S2, Global Center, High-tech Zone, Chengdu

Email: scimea@163.com 

Tel: (0086-)028-63859818   

Fax: (0086-)028-63859818   

Contact: (0086-)19113901604 (wechat:19113901604)


Follow Us
Copyright © 2009-2019 SCIMEA. All rights reserved 蜀ICP备19011649号-1