Recently, Jian‐Sheng Kang reported a strategy for protecting patients with COVID-19, based on vitamin intervention for cytokine storm. As the global pandemic is still growing, if the vitamin intervention for cytokine storm could be proved to be applicable and efficient, it would be tremendously helpful and easy to protect the patients with COVID‐19 worldwide from the cytokine storm‐related death.

Two recent clinical summaries of patients with COVID‐19 reported that cytokine storm was associated with the severity and death of patients with COVID‐19. Thus, it was urgent to seek effective prevention and treatments for the cytokine storm in COVID‐19 patients, especially those under intensive care unit (ICU). Interestingly, the oral administration of sufficient Vc might be sufficient to ameliorate the cytokine storm caused by neutrophils. In addition, 1‐10 nM of vitamin D (Vd) via vitamin D receptor (VDR) could efficiently suppress the cytokine production of Th17 by inducing the expression of C/EBP homologous protein (CHOP). Together, the simultaneous administration of sufficient Vc and Vd might ameliorate the neutrophil‐related cytokine storm in the patients with COVID‐19, especially those under ICU (Fig. 1).

Fig. 1 Vitamin Intervention for neutrophil‐related cytokine storm.

Article Access: https://onlinelibrary.wiley.com/doi/10.1002/mco2.7

Website for MedComm: https://onlinelibrary.wiley.com/journal/26882663

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